Heterogeneous nuclear ribonucleoprotein Q Recombinant Protein | HNRPQ recombinant protein

Recombinant Human Heterogeneous nuclear ribonucleoprotein Q

Cat. Num. AAA9421645

• Gene Names: SYNCRIP; PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Heterogeneous nuclear ribonucleoprotein Q; Recombinant Human Heterogeneous nuclear ribonucleoprotein Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBPNS1-associated protein 1Synaptotagmin-binding; cytoplasmic RNA-interacting protein; HNRPQ recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of 2-623aa, 2-191aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for HNRPQ recombinant protein

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complentation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly (A) and poly (U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assbles into the GAIT complex which binds to st loop-containing GAIT elents in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; ses not to be essential for GAIT complex function.

NCBI and Uniprot Product Information

• NCBI GI #: 228008396
• NCBI GeneID: 10492
• NCBI Accession #: NP_001153145.1
• NCBI GenBank Nucleotide #: NM_001159673.1
• UniProt Accession #: O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583; E1P501; E1P502
• Molecular Weight: 48.2kD
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein Q isoform 2
• NCBI Official Synonym Full Names: synaptotagmin binding cytoplasmic RNA interacting protein
• NCBI Official Symbol: SYNCRIP
• NCBI Official Synonym Symbols: PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein Q
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein Q
• Protein Family: Heterogeneous nuclear ribonucleoprotein
• UniProt Gene Name: SYNCRIP
• UniProt Synonym Gene Names: HNRPQ; NSAP1; hnRNP Q; GRY-RBP

NCBI Description

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

Uniprot Description

NSAP1: a heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. A component of the spliceosome. Five alternatively spliced isoforms have been described. Isoform 1, 2 and 3 are associated with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to ACF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins.

Protein type: Motility/polarity/chemotaxis; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 6q14.3

Cellular Component: membrane; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; RNA binding

Biological Process: negative regulation of translation; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA processing; RNA splicing