U6 snRNA-associated Sm-like protein LSm4 Recombinant Protein | LSM4 recombinant protein

Recombinant Human U6 snRNA-associated Sm-like protein LSm4

Cat. Num. AAA9420430

• Gene Names: LSM4; GRP; YER112W
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: U6 snRNA-associated Sm-like protein LSm4; Recombinant Human U6 snRNA-associated Sm-like protein LSm4; Glycine-rich protein; GRP; LSM4 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-139aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for LSM4 recombinant protein

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

NCBI and Uniprot Product Information

• NCBI GI #: 6912486
• NCBI GeneID: 25804
• NCBI Accession #: NP_036453.1
• NCBI GenBank Nucleotide #: NM_012321.4
• UniProt Accession #: Q9Y4Z0
• Molecular Weight: 31.34kD
• NCBI Official Full Name: U6 snRNA-associated Sm-like protein LSm4 isoform 1
• NCBI Official Synonym Full Names: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
• NCBI Official Symbol: LSM4
• NCBI Official Synonym Symbols: GRP; YER112W
• NCBI Protein Information: U6 snRNA-associated Sm-like protein LSm4
• UniProt Protein Name: U6 snRNA-associated Sm-like protein LSm4
• Protein Family: U6 snRNA-associated Sm-like protein
• UniProt Gene Name: LSM4
• UniProt Synonym Gene Names: GRP

NCBI Description

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

LSM4: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cytosol; membrane; nucleoplasm; protein complex

Molecular Function: PH domain binding; protein binding; RNA binding; U6 snRNA binding

Biological Process: cytoplasmic mRNA processing body assembly; nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosomal snRNP biogenesis; spliceosome assembly