Rabbit anti-Human CDKN1C Polyclonal Antibody | anti-CDKN1C antibody

CDKN1C antibody

Cat. Num. AAA9413487

• Gene Names: CDKN1C; BWS; WBS; p57; BWCR; KIP2; p57Kip2
• Reactivity: Human
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: CDKN1C; Polyclonal Antibody; CDKN1C antibody; BWCR; BWS; KIP2; WBS; p57; anti-CDKN1C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total CDKN1C antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 316

• Applicable Applications for anti-CDKN1C antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human CDKN1C.
• Target Name: CDKN1C
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of HeLa cell lines, using CDKN1C antibody.)

Related Product Information for anti-CDKN1C antibody

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).

Product Categories/Family for anti-CDKN1C antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557441
• NCBI GeneID: 1028
• NCBI Accession #: NP_000067.1
• NCBI GenBank Nucleotide #: NM_000076.2
• UniProt Accession #: P49918
• Molecular Weight: 31,040 Da
• NCBI Official Full Name: cyclin-dependent kinase inhibitor 1C isoform a
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 1C (p57, Kip2)
• NCBI Official Symbol: CDKN1C
• NCBI Official Synonym Symbols: BWS; WBS; p57; BWCR; KIP2; p57Kip2
• NCBI Protein Information: cyclin-dependent kinase inhibitor 1C
• UniProt Protein Name: Cyclin-dependent kinase inhibitor 1C
• Protein Family: Cyclin-dependent kinase inhibitor
• UniProt Gene Name: CDKN1C
• UniProt Synonym Gene Names: KIP2
• UniProt Entry Name: CDN1C_HUMAN

NCBI Description

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Description

p57Kip2: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life. Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver. Belongs to the CDI family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Tumor suppressor; Inhibitor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding

Biological Process: negative regulation of kinase activity; camera-type eye development; adrenal gland development; positive regulation of transcription, DNA-dependent; multicellular organism growth; regulation of mitotic cell cycle; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; uterus development; neuron maturation; negative regulation of phosphorylation; myeloid cell differentiation; cell cycle arrest; kidney development; negative regulation of transcription, DNA-dependent; skeletal development; negative regulation of epithelial cell proliferation; aging

Disease: Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies; Beckwith-wiedemann Syndrome