Rabbit SH3BP4 Polyclonal Antibody | anti-SH3BP4 antibody

SH3BP4 Antibody

Cat. Num. AAA9412200

• Gene Names: SH3BP4; TTP; BOG25
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: SH3BP4; Polyclonal Antibody; SH3BP4 Antibody; SH3 domain binding protein 4; TTP; BOG25; anti-SH3BP4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 963

• Applicable Applications for anti-SH3BP4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 18 amino acid peptide from near the carboxy terminus of human SH3BP4.
• Target Name: SH3BP4
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of SH3BP4 in rat lung tissue lysate with SH3BP4 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of SH3BP4 in human lung tissue with SH3BP4 antibody at 5 ug/mL.)

Related Product Information for anti-SH3BP4 antibody

SH3BP4 was initially isolated as a novel cDNA using differential display analysis using cultured human corneal fibroblasts. The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. SH3BP4 has been shown to interact with specific endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR) and localizes to TfR-containing coated pits and vesicles. It is thought to be involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of TfR. At least two isoforms of SH3BP4 are known to exist.

Product Categories/Family for anti-SH3BP4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 7657562
• NCBI GeneID: 23677
• NCBI Accession #: NP_055336
• NCBI GenBank Nucleotide #: NM_014521.2
• Molecular Weight: 60,337 Da
• NCBI Official Full Name: SH3 domain-binding protein 4
• NCBI Official Synonym Full Names: SH3-domain binding protein 4
• NCBI Official Symbol: SH3BP4
• NCBI Official Synonym Symbols: TTP; BOG25
• NCBI Protein Information: SH3 domain-binding protein 4
• UniProt Protein Name: SH3 domain-binding protein 4
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP4
• UniProt Synonym Gene Names: BOG25; EHB10; TTP
• UniProt Entry Name: SH3B4_HUMAN

NCBI Description

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

SH3BP4: Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Vesicle

Chromosomal Location of Human Ortholog: 2q37.1-q37.2

Cellular Component: clathrin-coated vesicle; cytoplasm; coated pit; nucleus

Molecular Function: identical protein binding; protein binding; Ras GTPase binding; GDP-dissociation inhibitor activity

Biological Process: negative regulation of cell proliferation; negative regulation of TOR signaling pathway; regulation of catalytic activity; endocytosis; negative regulation of cell growth; positive regulation of autophagy; amino acid import