Testing Data
(Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human Type II 5-phosphatase Polyclonal Antibody | anti-INPP5B antibody
Type II 5-phosphatase antibody
Immunohistochemistry: 1:100-1:250
Testing Data
(Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE Primary antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Ca922 xenograft, using INPP5B antibody at 1: 100 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Ca922 xenograft, using INPP5B antibody at 1: 100 dilution.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]
Uniprot Description
INPP5B: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: Golgi apparatus; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; ER-Golgi intermediate compartment; plasma membrane; integral to membrane; cytosol
Molecular Function: protein binding; metal ion binding; phosphoinositide 5-phosphatase activity
Biological Process: regulation of small GTPase mediated signal transduction; sperm motility; inositol phosphate metabolic process; in utero embryonic development; small GTPase mediated signal transduction; phosphoinositide dephosphorylation; spermatogenesis
Research Articles on INPP5B
Similar Products
Product Notes
The INPP5B inpp5b (Catalog #AAA9410371) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Type II 5-phosphatase antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Type II 5-phosphatase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:100-1:250. Researchers should empirically determine the suitability of the INPP5B inpp5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Type II 5-phosphatase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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