Rabbit anti-Human, Mouse APC1 Polyclonal Antibody | anti-APC1 antibody

APC1 Antibody

Cat. Num. AAA9410094

• Gene Names: ANAPC1; APC1; MCPR; TSG24
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: APC1; Polyclonal Antibody; APC1 Antibody; ANAPC1; Anaphase promoting complex subunit 1; ANC1; Cyclosome subunit 1; Mitotic checkpoint regulator; anti-APC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total APC1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 1944

• Applicable Applications for anti-APC1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from Internal of human APC1.
• Target Name: APC1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue using APC1 antibody.)

Related Product Information for anti-APC1 antibody

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.Joergensen P.M., Gene 262:51-59(2001).Ota T., Nat. Genet. 36:40-45(2004).Kraft C., EMBO J. 22:6598-6609(2003).

Product Categories/Family for anti-APC1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 12056971
• NCBI GeneID: 64682
• NCBI Accession #: NP_073153.1
• NCBI GenBank Nucleotide #: NM_022662.3
• UniProt Accession #: Q9H1A4; Q2M3H8; Q9BSE6; Q9H8D0
• Molecular Weight: 216,500 Da
• NCBI Official Full Name: anaphase-promoting complex subunit 1
• NCBI Official Synonym Full Names: anaphase promoting complex subunit 1
• NCBI Official Symbol: ANAPC1
• NCBI Official Synonym Symbols: APC1; MCPR; TSG24
• NCBI Protein Information: anaphase-promoting complex subunit 1
• UniProt Protein Name: Anaphase-promoting complex subunit 1
• Protein Family: Acetophenone carboxylase
• UniProt Gene Name: ANAPC1
• UniProt Synonym Gene Names: TSG24; APC1
• UniProt Entry Name: APC1_HUMAN

NCBI Description

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

Uniprot Description

APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family.

Protein type: Ubiquitin conjugating system; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q12.1

Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle