Rabbit anti-Human TSPYL1 Polyclonal Antibody | anti-TSPYL1 antibody

TSPYL1 antibody

Cat. Num. AAA9408114

• Gene Names: TSPYL1; TSPYL
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: TSPYL1; Polyclonal Antibody; TSPYL1 antibody; anti-TSPYL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 437

• Applicable Applications for anti-TSPYL1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500-1:3000; Immunohistochemistry: 1:100-1:500; Immunofluorescence: 1:100-1:200
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 213 of TSPYL1
• Target Name: TSPYL1
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample (30 ug of whole cell lysate) A: Molt-4 B: Raji 10% SDS PAGE Primary antibody diluted at 1: 1000)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded NCIN87 Xenograft, using TSPYL1 antibody at 1: 100 dilution.)

Immunofluorescence (IF)

(Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using TSPYL1 antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2500.)

Product Categories/Family for anti-TSPYL1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 62988322
• NCBI GeneID: 7259
• NCBI Accession #: NP_003300
• NCBI GenBank Nucleotide #: NM_003309.3
• Molecular Weight: 49,192 Da
• NCBI Official Full Name: testis-specific Y-encoded-like protein 1
• NCBI Official Synonym Full Names: TSPY-like 1
• NCBI Official Symbol: TSPYL1
• NCBI Official Synonym Symbols: TSPYL
• NCBI Protein Information: testis-specific Y-encoded-like protein 1
• UniProt Protein Name: Testis-specific Y-encoded-like protein 1
• Protein Family: Testis-specific Y-encoded-like protein
• UniProt Gene Name: TSPYL1
• UniProt Synonym Gene Names: TSPYL; TSPY-like protein 1
• UniProt Entry Name: TSYL1_HUMAN

NCBI Description

The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]

Uniprot Description

TSPYL1: Defects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: nucleolus; nucleus

Molecular Function: enzyme binding

Biological Process: nucleosome assembly

Disease: Sudden Infant Death With Dysgenesis Of The Testes Syndrome