Rabbit anti-Human, Mouse GAS41 Polyclonal Antibody | anti-GAS41 antibody

GAS41 Antibody

Cat. Num. AAA9404730

• Gene Names: YEATS4; YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GAS41; Polyclonal Antibody; GAS41 Antibody; YEATS domain-containing protein 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; anti-GAS41 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total GAS41 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 173

• Applicable Applications for anti-GAS41 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human GAS41.
• Target Name: GAS41
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from mouse lung cells, using GAS41 antibody.)

Related Product Information for anti-GAS41 antibody

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.Fischer U., Hum. Mol. Genet. 6:1817-1822(1997).Harborth J., J. Biol. Chem. 275:31979-31985(2000).Ota T., Nat. Genet. 36:40-45(2004).

Product Categories/Family for anti-GAS41 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 665821257
• NCBI GeneID: 8089
• NCBI Accession #: NP_001287879.1
• NCBI GenBank Nucleotide #: NM_001300950.1
• UniProt Accession #: O95619; Q9NQD0
• Molecular Weight: 26,499 Da
• NCBI Official Full Name: YEATS domain-containing protein 4 isoform 2
• NCBI Official Synonym Full Names: YEATS domain containing 4
• NCBI Official Symbol: YEATS4
• NCBI Official Synonym Symbols: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• NCBI Protein Information: YEATS domain-containing protein 4
• UniProt Protein Name: YEATS domain-containing protein 4
• UniProt Gene Name: YEATS4
• UniProt Synonym Gene Names: GAS41; Gas41; NuBI-1; NuBI1
• UniProt Entry Name: YETS4_HUMAN

NCBI Description

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of growth