Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse spleen tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes)
Rabbit anti-Human, Mouse KLK14 Polyclonal Antibody | anti-KLK14 antibody
KLK14 Antibody
Immunohistochemistry: 1:50-1:200
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse spleen tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes)
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse spleen tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/40.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/40.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Description
KLK14: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily.
Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.-
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: fertilization; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; epidermis morphogenesis; proteolysis
Research Articles on KLK14
Similar Products
Product Notes
The KLK14 klk14 (Catalog #AAA9403714) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KLK14 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KLK14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:200-1:1000 Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the KLK14 klk14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KLK14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
