Rabbit anti-Human PRODH Polyclonal Antibody | anti-PRODH antibody

PRODH Antibody

Cat. Num. AAA9402472

• Gene Names: PRODH; POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: PRODH; Polyclonal Antibody; PRODH Antibody; POX; PIG6; HSPOX2; PRODH1; PRODH2; anti-PRODH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total PRODH protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 492

• Applicable Applications for anti-PRODH antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human PRODH.
• Target Name: PRODH
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PRODH antibody.)

Related Product Information for anti-PRODH antibody

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-PRODH antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 304766647
• NCBI GeneID: 5625
• NCBI Accession #: NP_001182155.1
• NCBI GenBank Nucleotide #: NM_001195226.1
• UniProt Accession #: O43272; O14680; Q0P507; Q147W8; Q504W1; Q59FI8; Q6NV86; Q9UF13; A6NF53
• Molecular Weight: 59,231 Da
• NCBI Official Full Name: proline dehydrogenase 1, mitochondrial isoform 2
• NCBI Official Synonym Full Names: proline dehydrogenase (oxidase) 1
• NCBI Official Symbol: PRODH
• NCBI Official Synonym Symbols: POX; PIG6; HSPOX2; PRODH1; PRODH2; TP53I6
• NCBI Protein Information: proline dehydrogenase 1, mitochondrial
• UniProt Protein Name: Proline dehydrogenase 1, mitochondrial
• UniProt Gene Name: PRODH
• UniProt Synonym Gene Names: PIG6; POX2
• UniProt Entry Name: PROD_HUMAN

NCBI Description

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

Uniprot Description

PRODH: Converts proline to delta-1-pyrroline-5-carboxylate. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1). HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the proline oxidase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Amino Acid Metabolism - arginine and proline; Mitochondrial; EC 1.5.5.2

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrial matrix; mitochondrial inner membrane

Molecular Function: proline dehydrogenase activity

Biological Process: 4-hydroxyproline catabolic process; proline catabolic process; induction of apoptosis by oxidative stress; proline catabolic process to glutamate; proline metabolic process

Disease: Hyperprolinemia, Type I; Schizophrenia 4