Rabbit anti-Human PAK6 Polyclonal Antibody | anti-PAK6 antibody

PAK6 Antibody

Cat. Num. AAA9400732

• Gene Names: PAK6; PAK5
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: PAK6; Polyclonal Antibody; PAK6 Antibody; p21-activated kinase 6; anti-PAK6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 681

• Applicable Applications for anti-PAK6 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 13 amino acid peptide from near the center of human PAK6.
• Target Name: PAK6
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of PAK6 in Raji lysate with PAK6 antibody at (A) 1, (B) 2, and (C) 4 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of PAK6 in Raji cells with PAK6 antibody at 10 ug/mL.)

Related Product Information for anti-PAK6 antibody

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

Product Categories/Family for anti-PAK6 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 9910476
• NCBI GeneID: 56924
• NCBI Accession #: NP_064553
• NCBI GenBank Nucleotide #: NM_020168.5
• Molecular Weight: 69,777 Da
• NCBI Official Full Name: serine/threonine-protein kinase PAK 6 isoform 1
• NCBI Official Synonym Full Names: p21 protein (Cdc42/Rac)-activated kinase 6
• NCBI Official Symbol: PAK6
• NCBI Official Synonym Symbols: PAK5
• NCBI Protein Information: serine/threonine-protein kinase PAK 6
• UniProt Protein Name: Serine/threonine-protein kinase PAK 6
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PAK6
• UniProt Synonym Gene Names: PAK5; PAK-6
• UniProt Entry Name: PAK6_HUMAN

NCBI Description

This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Description

PAK6: a protein kinase of the STE20 family. Interacts with androgen receptor (AR), and cotranslocates into the nucleus with AR in response to androgen. Highly expressed in testis and prostate tissues.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; Nuclear receptor co-regulator; STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: regulation of transcription, DNA-dependent; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; protein amino acid phosphorylation