Bovine tRNA (Cytosine(34)-C(5))-Methyltransferase (NSUN2) ELISA Kit | NSUN2 elisa kit
Bovine tRNA (Cytosine(34)-C(5))-Methyltransferase (NSUN2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]
Uniprot Description
NSUN2: an RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Not able to modify tRNAs at positions 48 or 49. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. Interacts with NPM1 and NCL during interphase. Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA. Defects in NSUN2 are the cause of mental retardation autosomal recessive type 5 (MRT5), a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily. Two human isoforms produced by alternative splicing.
Protein type: EC 2.1.1.203; Methyltransferase; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 5p15.31
Cellular Component: cytoplasm; nucleolus; nucleoplasm; spindle
Molecular Function: RNA binding; tRNA (cytosine-5-)-methyltransferase activity; tRNA binding
Biological Process: cell division; hair follicle maturation; meiotic cell cycle checkpoint; spermatid development; tRNA methylation; tRNA modification
Disease: Mental Retardation, Autosomal Recessive 5
Research Articles on NSUN2
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Product Notes
The Bovine NSUN2 nsun2 (Catalog #AAA9397896) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9397896 ELISA Kit recognizes Bovine NSUN2. It is sometimes possible for the material contained within the vial of "tRNA (Cytosine(34)-C(5))-Methyltransferase (NSUN2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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