Hamster Homeobox A13 (HOXA13) ELISA Kit | HOXA13 elisa kit
Hamster Homeobox A13 (HOXA13) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
Uniprot Description
HOXA13: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA13 are the cause of hand-foot-genital syndrome (HFGS); also known as hand-foot-uterus syndrome. The clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract. Defects in HOXA13 are the cause of Guttmacher syndrome (GUTTS). Guttmacher syndrome is a dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot- genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. Belongs to the Abd-B homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component: intermediate filament cytoskeleton; nucleus
Molecular Function: DNA binding
Biological Process: skeletal development
Disease: Hand-foot-genital Syndrome; Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias
Research Articles on HOXA13
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Product Notes
The Hamster HOXA13 hoxa13 (Catalog #AAA9374211) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9374211 ELISA Kit recognizes Hamster HOXA13. It is sometimes possible for the material contained within the vial of "Homeobox A13 (HOXA13), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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