Plant Coiled Coil and C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit | CC2D1A elisa kit

Plant Coiled Coil and C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit

• Gene Names: CC2D1A; MRT3; FREUD-1; Freud-1/Aki1
• Reactivity: Plant
• Synonyms: Coiled Coil and C2 Domain Containing Protein 1A (CC2D1A); Plant Coiled Coil and C2 Domain Containing Protein 1A (CC2D1A) ELISA Kit; CC2D1A elisa kit

• Reactivity: Plant
• Sequence Length: 951

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 96974985
• NCBI GeneID: 54862
• NCBI Accession #: NP_060191.3
• NCBI GenBank Nucleotide #: NM_017721.4
• Molecular Weight: 103,934 Da
• NCBI Official Full Name: coiled-coil and C2 domain-containing protein 1A
• NCBI Official Synonym Full Names: coiled-coil and C2 domain containing 1A
• NCBI Official Symbol: CC2D1A
• NCBI Official Synonym Symbols: MRT3; FREUD-1; Freud-1/Aki1
• NCBI Protein Information: coiled-coil and C2 domain-containing protein 1A
• UniProt Protein Name: Coiled-coil and C2 domain-containing protein 1A
• Protein Family: Coiled-coil and C2 domain-containing protein
• UniProt Gene Name: CC2D1A
• UniProt Synonym Gene Names: AKI1; FRE under dual repression-binding protein 1; Freud-1
• UniProt Entry Name: C2D1A_HUMAN

NCBI Description

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.[provided by RefSeq, Oct 2009]

Uniprot Description

CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; nucleus

Molecular Function: protein binding; signal transducer activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade

Disease: Mental Retardation, Autosomal Recessive 3