Human DBF4 homolog B (S. cerevisiae) ELISA Kit | DBF4B elisa kit
Human Protein DBF4 homolog B, DBF4B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Uniprot Description
DBF4B: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 17q21.31|17q21
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nuclear chromatin; cytoplasm; nucleus
Molecular Function: nucleic acid binding; zinc ion binding; protein kinase activator activity; protein kinase binding
Biological Process: positive regulation of protein kinase activity; positive regulation of cell proliferation; cell cycle
Research Articles on DBF4B
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Product Notes
The Human DBF4B dbf4b (Catalog #AAA9343036) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343036 ELISA Kit recognizes Human DBF4B. It is sometimes possible for the material contained within the vial of "DBF4 homolog B (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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