Mouse eukaryotic translation initiation factor 4 gamma, 2 ELISA Kit | EIF4G2 elisa kit

Mouse Eukaryotic translation initiation factor 4 gamma 2, EIF4G2 ELISA Kit

Cat. Num. AAA9342243

• Gene Names: Eif4g2; p97; Nat1; DAP-5; Natm1; AA589388; E130105L11Rik
• Reactivity: Mouse
• Synonyms: eukaryotic translation initiation factor 4 gamma; 2; Mouse Eukaryotic translation initiation factor 4 gamma 2; EIF4G2 ELISA Kit; Mouse Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) ELISA kit; AAG1; DAP5; FLJ41344; NAT1; p97; aging-associated protein 1; death-associated protein 5; eIF-4-gamma 2; eukaryotic translation initiation factor 4G-like 1; EIF4G2 elisa kit

• Reactivity: Mouse
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Serum, Plasma and Tissue Homogenate
• Detection Range: 0.5 ng/ml-16 ng/ml.
• Sensitivity: 0.1ng/ml.
• Assay Type: Sandwich
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for EIF4G2 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of EIF4G2 (hereafter termed this analyte) in undiluted original Mouse serum, plasma and tissue homogenate samples.

NCBI and Uniprot Product Information

• NCBI GI #: 110630015
• NCBI GeneID: 13690
• NCBI Accession #: NP_001035221.1
• NCBI GenBank Nucleotide #: NM_001040131.2
• UniProt Accession #: Q62448; P97867; Q0VGZ3; Q3UNC1; Q5XKD8; Q6P1Z0; Q921U3
• Molecular Weight: 102,106 Da
• NCBI Official Full Name: eukaryotic translation initiation factor 4 gamma 2 isoform 2
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 4, gamma 2
• NCBI Official Symbol: Eif4g2
• NCBI Official Synonym Symbols: p97; Nat1; DAP-5; Natm1; AA589388; E130105L11Rik
• NCBI Protein Information: eukaryotic translation initiation factor 4 gamma 2; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; novel APOBEC-1 target 1; translation repressor Nat1
• UniProt Protein Name: Eukaryotic translation initiation factor 4 gamma 2
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: Eif4g2
• UniProt Synonym Gene Names: Nat1; eIF-4-gamma 2; eIF-4G 2; eIF4G 2
• UniProt Entry Name: IF4G2_MOUSE

NCBI Description

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

EIF4G2: a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases.

Protein type: Translation initiation; RNA-binding; Translation

Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytoplasm

Molecular Function: protein binding; RNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: regulation of translation; translation; translational initiation; regulation of translational initiation