Human glucocorticoid receptor DNA binding factor 1 ELISA Kit | GRLF1 elisa kit
Human Rho GTPase-activating protein 35, GRLF1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
Uniprot Description
GRF-1: the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described.
Protein type: GAPs, Rac/Rho; Tumor suppressor; GAPs; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: nucleus; cytosol; actin cytoskeleton
Molecular Function: DNA binding; GTP binding; transcription corepressor activity
Biological Process: regulation of cell shape; axon guidance; regulation of small GTPase mediated signal transduction; camera-type eye development; negative regulation of Rho protein signal transduction; transcription, DNA-dependent; small GTPase mediated signal transduction; neural tube closure; forebrain development; negative regulation of vascular permeability; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on GRLF1
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Product Notes
The Human GRLF1 arhgap35 (Catalog #AAA9341912) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341912 ELISA Kit recognizes Human GRLF1. It is sometimes possible for the material contained within the vial of "glucocorticoid receptor DNA binding factor 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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