Mouse vitamin D (1, 25- dihydroxyvitamin D3) receptor ELISA Kit | VDR elisa kit
Mouse Vitamin D3 receptor, VDR ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
VDR: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily.
Protein type: Transcription factor; Nuclear receptor; DNA-binding
Cellular Component: heterochromatin; nuclear matrix; intracellular membrane-bound organelle; cell; T-tubule; nuclear heterochromatin; caveola; cytosol; nucleoplasm; euchromatin; dense fibrillar component; perinuclear region of cytoplasm; nucleus; receptor complex
Molecular Function: retinoid X receptor binding; vitamin D binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; steroid hormone receptor activity; vitamin D3 receptor activity; transcription factor activity
Biological Process: lactation; transcription from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; multicellular organismal development; positive regulation of apoptosis involved in mammary gland involution; cell morphogenesis; regulation of calcium ion transport; negative regulation of transcription from RNA polymerase II promoter; intestinal absorption; cellular calcium ion homeostasis; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; organ morphogenesis; regulation of transcription, DNA-dependent; calcium ion transport; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; skeletal development; positive regulation of keratinocyte differentiation
Research Articles on VDR
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Product Notes
The Mouse VDR vdr (Catalog #AAA9340676) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9340676 ELISA Kit recognizes Mouse VDR. It is sometimes possible for the material contained within the vial of "vitamin D (1, 25- dihydroxyvitamin D3) receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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