Human MAP kinase interacting serine/threonine kinase 1 ELISA Kit | MKNK1 elisa kit

Human MAP kinase-interacting serine/threonine-protein kinase 1, MKNK1 ELISA Kit

Cat. Num. AAA9340465

• Gene Names: MKNK1; MNK1
• Reactivity: Human
• Synonyms: MAP kinase interacting serine/threonine kinase 1; Human MAP kinase-interacting serine/threonine-protein kinase 1; MKNK1 ELISA Kit; Human MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) ELISA kit; RP11-49P4.3; MNK1; MAP kinase interacting kinase 1; MAP kinase-interacting serine/threonine kinase 1; MKNK1 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
• Assay Type: Sandwich (Quantitative)
• Detection Range: 0.625ng/ml-20ng/ml.
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for MKNK1 elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of MKNK1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 207113186
• NCBI GeneID: 8569
• NCBI Accession #: NP_001129025.1
• NCBI GenBank Nucleotide #: NM_001135553.2
• UniProt Accession #: Q9BUB5; O00312; Q5TC06; Q5TC07; Q6V0N6; D3DQ20; D3DQ21
• Molecular Weight: 51,342 Da
• NCBI Official Full Name: MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3
• NCBI Official Synonym Full Names: MAP kinase interacting serine/threonine kinase 1
• NCBI Official Symbol: MKNK1
• NCBI Official Synonym Symbols: MNK1
• NCBI Protein Information: MAP kinase-interacting serine/threonine-protein kinase 1; MAPK signal-integrating kinase 1; MAP kinase signal-integrating kinase 1
• UniProt Protein Name: MAP kinase-interacting serine/threonine-protein kinase 1
• Protein Family: MAP kinase-interacting serine/threonine-protein kinase
• UniProt Gene Name: MKNK1
• UniProt Synonym Gene Names: MNK1; MAPK signal-integrating kinase 1; Mnk1
• UniProt Entry Name: MKNK1_HUMAN

NCBI Description

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described.

Protein type: Kinase, protein; Translation; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; MAPKAPK family; MNK subfamily

Chromosomal Location of Human Ortholog: 1p33

Cellular Component: cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: peptidyl-serine phosphorylation; fibroblast growth factor receptor signaling pathway; protein amino acid phosphorylation; response to salt stress; regulation of translational initiation