Mouse FRAS1 related extracellular matrix 1 ELISA Kit | FREM1 elisa kit
Mouse FRAS1-related extracellular matrix protein 1, FREM1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
FREM1: Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Defects in FREM1 are the cause of bifid nose with or without anorectal and renal anomalies (BNAR). A bifid nose is a rare congenital deformity due to failure of the paired nasal processes to fuse to a single midline organ during early gestation. BNAR is an autosomal recessive disorder and patients usually present a bifid nose associated with renal and anorectal malformations. Defects in FREM1 are the cause of Manitoba oculotrichoanal syndrome (MOTA). MOTA is a rare condition defined by eyelid colobomas, cryptophthalmos, and anophthalmia/microphthalmia, an aberrant hairline, a bifid or broad nasal tip, and gastrointestinal anomalies such as omphalocele and anal stenosis. Defects in FREM1 are the cause of trigonocephaly type 2 (TRIGNO2). TRIGNO2 is a keel-shaped deformation of the forehead, caused by premature fusion of the metopic sutures. It results in a triangular shape of the head. Belongs to the FRAS1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: proteinaceous extracellular matrix; integral to membrane; extracellular region; basement membrane
Molecular Function: metal ion binding; carbohydrate binding
Biological Process: multicellular organismal development; cell-matrix adhesion; cell communication; cell adhesion
Research Articles on FREM1
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Product Notes
The Mouse FREM1 frem1 (Catalog #AAA9339680) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339680 ELISA Kit recognizes Mouse FREM1. It is sometimes possible for the material contained within the vial of "FRAS1 related extracellular matrix 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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