Mouse sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) ELISA Kit | SIRT2 elisa kit
Mouse NAD-dependent deacetylase sirtuin-2, SIRT2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SIRT2: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.-; Deacetylase
Cellular Component: microtubule; centrosome; lateral loop; paranode region of axon; perikaryon; chromosome; nuclear heterochromatin; cytosol; centriole; cell projection; cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; spindle; midbody; nucleus; myelin sheath
Molecular Function: (3,5-dichlorophenylurea)acetate amidohydrolase activity; ubiquitin binding; zinc ion binding; hydrolase activity; histone deacetylase binding; metal ion binding; protein deacetylase activity; beta-tubulin binding; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; transcription factor binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; N-acetylgalactosamine-6-phosphate deacetylase activity; histone acetyltransferase binding; N2-acetyl-L-lysine deacetylase activity; iprodione amidohydrolase activity; protein binding; tubulin deacetylase activity; indoleacetamide hydrolase activity; protein N-terminal asparagine amidohydrolase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; histone deacetylase activity; O-succinylbenzoate synthase activity; NAD binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; negative regulation of autophagy; phosphoinositide 3-kinase cascade; regulation of myelination; regulation of cell cycle; regulation of fat cell differentiation; positive regulation of attachment of spindle microtubules to kinetochore; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; meiotic cell cycle; protein amino acid deacetylation; regulation of transcription, DNA-dependent; cellular lipid catabolic process; protein kinase B signaling cascade; cell differentiation; positive regulation of DNA binding; mitosis; nervous system development; transcription, DNA-dependent; positive regulation of meiosis; histone deacetylation; hepatocyte growth factor receptor signaling pathway; negative regulation of fat cell differentiation; cell cycle; negative regulation of striated muscle development; myelination in the peripheral nervous system; negative regulation of oligodendrocyte differentiation; cell division; positive regulation of cell division; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; autophagy; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process; negative regulation of apoptosis
Research Articles on SIRT2
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Product Notes
The Mouse SIRT2 sirt2 (Catalog #AAA9339061) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339061 ELISA Kit recognizes Mouse SIRT2. It is sometimes possible for the material contained within the vial of "sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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