Human ubiquitin-conjugating enzyme E2T (putative) ELISA Kit | UBE2T elisa kit
Human Ubiquitin-conjugating enzyme E2 T, UBE2T ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]
Uniprot Description
UBE2T: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; Ligase
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; chromatin binding; ATP binding; ligase activity
Biological Process: protein monoubiquitination; protein autoubiquitination; DNA repair; response to DNA damage stimulus
Disease: Fanconi Anemia, Complementation Group T
Research Articles on UBE2T
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Product Notes
The Human UBE2T ube2t (Catalog #AAA9338696) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338696 ELISA Kit recognizes Human UBE2T. It is sometimes possible for the material contained within the vial of "ubiquitin-conjugating enzyme E2T (putative), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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