Human l (3) mbt-like (Drosophila) ELISA Kit | L3MBTL elisa kit
Human Lethal, L3MBTL ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Uniprot Description
L3MBTL: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Histone-binding
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: nucleoplasm; plasma membrane; nucleolus; condensed chromosome; nucleus; chromatin
Molecular Function: identical protein binding; protein binding; nucleosomal histone binding; histone binding; zinc ion binding; nucleosome binding; SAM domain binding; chromatin binding; transcription factor activity; methylated histone residue binding
Biological Process: transcription, DNA-dependent; regulation of cell cycle; regulation of megakaryocyte differentiation; regulation of mitosis; hemopoiesis; chromatin modification; negative regulation of transcription, DNA-dependent
Research Articles on L3MBTL
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Product Notes
The Human L3MBTL l3mbtl1 (Catalog #AAA9337773) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337773 ELISA Kit recognizes Human L3MBTL. It is sometimes possible for the material contained within the vial of "l (3) mbt-like (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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