Rat poly-U binding splicing factor 60KDa ELISA Kit | PUF60 elisa kit

Rat Poly (U) -binding-splicing factor PUF60, PUF60 ELISA Kit

Cat. Num. AAA9337136

• Gene Names: Puf60; Siahbp1
• Reactivity: Rat
• Synonyms: poly-U binding splicing factor 60KDa; Rat Poly (U) -binding-splicing factor PUF60; PUF60 ELISA Kit; Rat Poly (U) -binding-splicing factor PUF60 (PUF60) ELISA kit; FIR; FLJ31379; RoBPI; SIAHBP1; FBP interacting repressor; Ro ribonucleoprotein binding protein 1; Ro ribonucleoprotein-binding protein 1; fuse-binding protein-interacting repressor; poly-U binding splic; PUF60 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 158563997
• NCBI GeneID: 84401
• UniProt Accession #: Q9WV25
• Molecular Weight: 60,249 Da
• NCBI Official Full Name: Poly(U)-binding-splicing factor PUF60
• NCBI Official Synonym Full Names: poly-U binding splicing factor 60
• NCBI Official Symbol: Puf60
• NCBI Official Synonym Symbols: Siahbp1
• NCBI Protein Information: poly(U)-binding-splicing factor PUF60; poly(U)-binding-splicing factor PUF60; siah-binding protein 1; FBP interacting repressor; RNA-binding protein Siah-BP; poly-U binding splicing factor 60K; 60 kDa poly(U)-binding-splicing factor; Ro ribonucleoprotein-binding protein 1; pyrimidine tract binding splicing factor; siah binding protein 1; FBP interacting repressor; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1
• UniProt Protein Name: Poly(U)-binding-splicing factor PUF60
• Protein Family: Poly(U)-binding-splicing factor
• UniProt Gene Name: Puf60
• UniProt Synonym Gene Names: Siahbp1
• UniProt Entry Name: PUF60_RAT

NCBI Description

RNA-binding protein [RGD, Feb 2006]

Uniprot Description

FIR: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA (By similarity)

Protein type: RNA-binding; RNA splicing; Spliceosome; Transcription, coactivator/corepressor