Mouse ubiquitin-conjugating enzyme E2W (putative) ELISA Kit | UBE2W elisa kit
Mouse Probable ubiquitin-conjugating enzyme E2 W, UBE2W ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
UBE2W: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Enzyme, misc.; EC 6.3.2.19; Ubiquitin ligase; Ligase
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; nucleotide binding; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; misfolded or incompletely synthesized protein catabolic process; DNA repair; response to DNA damage stimulus
Research Articles on UBE2W
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Product Notes
The Mouse UBE2W ube2w (Catalog #AAA9337013) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337013 ELISA Kit recognizes Mouse UBE2W. It is sometimes possible for the material contained within the vial of "ubiquitin-conjugating enzyme E2W (putative), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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