Mouse diaphanous homolog 3 (Drosophila) ELISA Kit | DIAPH3 elisa kit
Mouse Protein diaphanous homolog 3, DIAPH3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
Diaphanous-3: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Defects in DIAPH3 are the cause of auditory neuropathy, autosomal dominant, type 1 (AUNA1). A form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem. A disease- causing mutation in the conserved 5'-UTR leads to increased protein expression (PubMed:20624953). Belongs to the formin homology family. Diaphanous subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis
Cellular Component: cytoplasm; nucleus
Molecular Function: Rho GTPase binding; actin binding
Biological Process: cellular component organization and biogenesis; actin cytoskeleton organization and biogenesis
Research Articles on DIAPH3
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Product Notes
The Mouse DIAPH3 diaph3 (Catalog #AAA9336359) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336359 ELISA Kit recognizes Mouse DIAPH3. It is sometimes possible for the material contained within the vial of "diaphanous homolog 3 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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