Human ring finger protein 43 ELISA Kit | RNF43 elisa kit

Human RING finger protein 43, RNF43 ELISA Kit

Cat. Num. AAA9336145

• Gene Names: RNF43; URCC; RNF124
• Reactivity: Human
• Synonyms: ring finger protein 43; Human RING finger protein 43; RNF43 ELISA Kit; Human RING finger protein 43 (RNF43) ELISA kit; DKFZp781H02126; DKFZp781H0392; FLJ20315; FLJ77466; FLJ99338; MGC125630; RNF124; URCC; ; RNF43 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 31.2pg/ml-1000pg/ml
• Sensitivity: 5.0pg/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for RNF43 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of RNF43 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 56711322
• NCBI GeneID: 54894
• NCBI Accession #: NP_060233.3
• NCBI GenBank Nucleotide #: NM_017763.4
• UniProt Accession #: Q68DV7; Q65ZA4; Q6AI04; Q9NXD0; A8K4R2; B7Z443; B7Z5D5; B7Z5J5
• Molecular Weight: 85,722 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF43
• NCBI Official Synonym Full Names: ring finger protein 43
• NCBI Official Symbol: RNF43
• NCBI Official Synonym Symbols: URCC; RNF124
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF43
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF43
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF43
• UniProt Entry Name: RNF43_HUMAN

NCBI Description

RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008]

Uniprot Description

RNF43: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Belongs to the ZNRF3 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Membrane protein, integral; Ligase; Ubiquitin ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; nuclear envelope

Molecular Function: protein binding; zinc ion binding; frizzled binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination