Mouse regulation of nuclear pre-mRNA domain containing 1B ELISA Kit | RPRD1B elisa kit
Mouse Regulation of nuclear pre-mRNA domain-containing protein 1B, RPRD1B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RPRD1B: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Belongs to the UPF0400 (RTT103) family.
Protein type: Motility/polarity/chemotaxis
Cellular Component: DNA-directed RNA polymerase II, holoenzyme; nucleus
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
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Product Notes
The Mouse RPRD1B rprd1b (Catalog #AAA9335607) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335607 ELISA Kit recognizes Mouse RPRD1B. It is sometimes possible for the material contained within the vial of "regulation of nuclear pre-mRNA domain containing 1B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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