Human regulator of chromosome condensation 1 ELISA Kit | RCC1 elisa kit
Human Regulator of chromosome condensation, RCC1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RCC1: a guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP for GTP. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Ras; Cell cycle regulation; GEFs
Chromosomal Location of Human Ortholog: 1p36.1
Cellular Component: nucleoplasm; nuclear membrane; condensed nuclear chromosome; nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein binding; nucleosomal DNA binding; Ran guanyl-nucleotide exchange factor activity; histone binding; chromatin binding
Biological Process: mitosis; mitotic spindle organization and biogenesis; viral reproduction; cell division; regulation of mitosis; spindle assembly; G1/S transition of mitotic cell cycle; chromosome segregation
Research Articles on RCC1
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Product Notes
The Human RCC1 rcc1 (Catalog #AAA9335101) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335101 ELISA Kit recognizes Human RCC1. It is sometimes possible for the material contained within the vial of "regulator of chromosome condensation 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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