Mouse ring finger protein 170 ELISA Kit | RNF170 elisa kit
Mouse RING finger protein 170, RNF170 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RNF170: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Defects in RNF170 are the cause of ataxia, sensory, type 1, autosomal dominant (SNAX1). A rare disease characterized by progressive ataxia caused by degeneration of the posterior columns of the spinal cord. Affected individuals have a reduced ability to feel pain, temperature and vibration, particularly in the hands and feet. Their most prominent feature is an ataxic gait resulting from a severe loss of proprioception. Thus, patients rely on visual cues for maintaining proper body posture, such that they are unable to remain upright if their eyes are closed (Romberg sign). 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: membrane; endoplasmic reticulum; integral to membrane
Molecular Function: zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
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Product Notes
The Mouse RNF170 rnf170 (Catalog #AAA9334939) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334939 ELISA Kit recognizes Mouse RNF170. It is sometimes possible for the material contained within the vial of "ring finger protein 170, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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