Human leucyl-tRNA synthetase ELISA Kit | LARS elisa kit
Human Leucyl-tRNA synthetase, cytoplasmic, LARS ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Uniprot Description
LARS: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; EC 6.1.1.4; Translation; Ligase
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: methionine-tRNA ligase activity; leucine-tRNA ligase activity; protein binding; ATP binding
Biological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; methionyl-tRNA aminoacylation; gene expression
Disease: Infantile Liver Failure Syndrome 1
Research Articles on LARS
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Product Notes
The Human LARS lars (Catalog #AAA9334832) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334832 ELISA Kit recognizes Human LARS. It is sometimes possible for the material contained within the vial of "leucyl-tRNA synthetase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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