Human ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 ELISA Kit | ATP8A2 elisa kit
Human Probable phospholipid-transporting ATPase IB, ATP8A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ). In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Uniprot Description
ATP8A2 iso1: Belongs to the cation transport ATPase (P-type) family. Type IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.1; Transporter; Hydrolase; Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: Golgi apparatus; photoreceptor outer segment; integral to membrane; plasma membrane; endosome
Molecular Function: phospholipid-translocating ATPase activity; magnesium ion binding; ATP binding
Biological Process: skin development; inner ear morphogenesis; metabolic process; eating behavior; involuntary skeletal muscle contraction; positive regulation of multicellular organism growth; phospholipid translocation; negative regulation of cell proliferation; neuromuscular process controlling posture; axonogenesis; neurofilament cytoskeleton organization and biogenesis; detection of light stimulus involved in visual perception; neuron development; aging
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 4
Research Articles on ATP8A2
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Product Notes
The Human ATP8A2 atp8a2 (Catalog #AAA9334484) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334484 ELISA Kit recognizes Human ATP8A2. It is sometimes possible for the material contained within the vial of "ATPase, aminophospholipid transporter-like, class I, type 8A, member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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