Mouse eukaryotic translation initiation factor 2-alpha kinase 1 ELISA Kit | EIF2AK1 elisa kit
Mouse Eukaryotic translation initiation factor 2-alpha kinase 1, EIF2AK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HRI: a protein kinase of the PEK family. Phosphorylates the alpha subunit of eukaryotic initiation factor 2 in response to various stress conditions, inhibiting protein synthesis at the level of initiation. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity. Requires association with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosporylation. Two alternatively spliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, Other; EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family
Cellular Component: cytoplasm
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; heme binding; kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding; protein kinase activity
Biological Process: regulation of translation; negative regulation of cell proliferation; iron ion homeostasis; macrophage differentiation; protoporphyrinogen IX metabolic process; negative regulation of translation; regulation of hemoglobin biosynthetic process; protein amino acid phosphorylation; phosphorylation; phagocytosis; acute inflammatory response; negative regulation of hemoglobin biosynthetic process
Research Articles on EIF2AK1
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Product Notes
The Mouse EIF2AK1 eif2ak1 (Catalog #AAA9332863) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332863 ELISA Kit recognizes Mouse EIF2AK1. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 2-alpha kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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