Mouse tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase ELISA Kit | TNKS elisa kit
Mouse Tankyrase-1, TNKS ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TNKS: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.4.2.30; Transferase
Cellular Component: Golgi apparatus; chromosome, telomeric region; cytoskeleton; membrane; nuclear chromosome, telomeric region; cytoplasm; nuclear pore; chromosome; nucleus; cytosol; chromosome, pericentric region
Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; zinc ion binding; metal ion binding; NAD+ ADP-ribosyltransferase activity
Biological Process: mitosis; mRNA transport; protein polyubiquitination; Wnt receptor signaling pathway; peptidyl-threonine phosphorylation; spindle assembly; cell cycle; negative regulation of DNA binding; positive regulation of telomere maintenance via telomerase; protein amino acid ADP-ribosylation; peptidyl-serine phosphorylation; protein transport; cell division; transport; positive regulation of transcription from RNA polymerase II promoter
Research Articles on TNKS
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Product Notes
The Mouse TNKS tnks (Catalog #AAA9332308) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332308 ELISA Kit recognizes Mouse TNKS. It is sometimes possible for the material contained within the vial of "tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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