Human ATPase, H+ transporting, lysosomal accessory protein 2 ELISA Kit | ATP6AP2 elisa kit

Human Renin receptor, ATP6AP2 ELISA Kit

Cat. Num. AAA9332088

• Gene Names: ATP6AP2; PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal accessory protein 2; Human Renin receptor; ATP6AP2 ELISA Kit; Human Renin receptor (ATP6AP2) ELISA kit; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MGC99577; MRXE; MSTP009; XMRE; lysosomal (vacuolar proton pump) membrane sector associated protein M8-9; H+ transpor; ATP6AP2 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 15011918
• NCBI GeneID: 10159
• NCBI Accession #: NP_005756.2
• NCBI GenBank Nucleotide #: NM_005765.2
• UniProt Accession #: O75787; Q5QTQ7; Q6T7F5; Q8NBP3; Q8NG15; Q96FV6; Q96LB5; Q9H2P8; Q9UG89
• Molecular Weight: 39,008 Da
• NCBI Official Full Name: renin receptor
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal accessory protein 2
• NCBI Official Symbol: ATP6AP2
• NCBI Official Synonym Symbols: PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9
• NCBI Protein Information: renin receptor; N14F; prorenin receptor; V-ATPase M8.9 subunit; renin/prorenin receptor; ER-localized type I transmembrane adaptor; embryonic liver differentiation factor 10; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal interacting protein 2; vacuolar ATP synthase membrane sector-associated protein M8-9; vacuolar proton ATP synthase membrane sector associated protein M8-9; ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9
• UniProt Protein Name: Renin receptor
• Protein Family: Renin receptor
• UniProt Gene Name: ATP6AP2
• UniProt Synonym Gene Names: ATP6IP2; CAPER; ELDF10; HT028; MSTP009; PSEC0072; ATP6M8-9; V-ATPase M8.9 subunit
• UniProt Entry Name: RENR_HUMAN

NCBI Description

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: neuron projection; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; enzyme binding; receptor activity; aspartic-type endopeptidase activity

Biological Process: rostrocaudal neural tube patterning; positive regulation of transforming growth factor-beta1 production; cellular protein metabolic process; regulation of MAPKKK cascade; angiotensin maturation; proteolysis; positive regulation of Wnt receptor signaling pathway; eye pigmentation

Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked