Human neurofibromin 2 (merlin) ELISA Kit | NF2 elisa kit
Human Merlin, NF2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
Uniprot Description
Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; adherens junction; extrinsic to membrane; cytoskeleton; membrane; lamellipodium; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow
Molecular Function: protein binding; actin binding
Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; negative regulation of cell proliferation; Schwann cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; positive regulation of cell differentiation; actin cytoskeleton organization and biogenesis; negative regulation of cell migration; negative regulation of JAK-STAT cascade
Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
Research Articles on NF2
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Product Notes
The Human NF2 nf2 (Catalog #AAA9331611) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331611 ELISA Kit recognizes Human NF2. It is sometimes possible for the material contained within the vial of "neurofibromin 2 (merlin), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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