Human proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 ELISA Kit | PSMD14 elisa kit

Human 26S proteasome non-ATPase regulatory subunit 14, PSMD14 ELISA Kit

Cat. Num. AAA9331133

• Gene Names: PSMD14; PAD1; POH1; RPN11
• Reactivity: Human
• Synonyms: proteasome (prosome; macropain) 26S subunit; non-ATPase; 14; Human 26S proteasome non-ATPase regulatory subunit 14; PSMD14 ELISA Kit; Human 26S proteasome non-ATPase regulatory subunit 14 (PSMD14) ELISA kit; PAD1; POH1; RPN11; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated pad1 homolog; proteasome 26S subunit; non-ATPase 14; PSMD14 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.25ng/ml-8ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for PSMD14 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of PSMD14 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 5031981
• NCBI GeneID: 10213
• NCBI Accession #: NP_005796.1
• NCBI GenBank Nucleotide #: NM_005805.5
• UniProt Accession #: O00487; O00176; B3KNW2
• Molecular Weight: 34,577 Da
• NCBI Official Full Name: 26S proteasome non-ATPase regulatory subunit 14
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
• NCBI Official Symbol: PSMD14
• NCBI Official Synonym Symbols: PAD1; POH1; RPN11
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated PAD1 homolog 1
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 14
• UniProt Gene Name: PSMD14
• UniProt Synonym Gene Names: POH1
• UniProt Entry Name: PSDE_HUMAN

NCBI Description

This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]

Uniprot Description

PSMD14: a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.

Protein type: Proteasome complex; Protease; EC 3.4.19.-

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: proteasome complex; nucleoplasm; nucleus; cytosol

Molecular Function: metallopeptidase activity; metal ion binding

Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis