Human arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) ELISA Kit | ASNA1 elisa kit

Human ATPase ASNA1, ASNA1 ELISA Kit

Cat. Num. AAA9330551

• Gene Names: ASNA1; GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I
• Reactivity: Human
• Synonyms: arsA arsenite transporter; ATP-binding; homolog 1 (bacterial); Human ATPase ASNA1; ASNA1 ELISA Kit; Human ATPase ASNA1 (ASNA1) ELISA kit; ARSA-I; ARSA1; MGC3821; homolog 1; ASNA1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 50428938
• NCBI GeneID: 439
• NCBI Accession #: NP_004308.2
• NCBI GenBank Nucleotide #: NM_004317.2
• UniProt Accession #: O43681; Q53FC6; Q92849; A6NHP8; A8K740
• Molecular Weight: 38,793 Da
• NCBI Official Full Name: ATPase ASNA1
• NCBI Official Synonym Full Names: arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
• NCBI Official Symbol: ASNA1
• NCBI Official Synonym Symbols: GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I
• NCBI Protein Information: ATPase ASNA1; arsenite-stimulated ATPase; arsenical pump-driving ATPase; golgi to ER traffic 3 homolog; transmembrane domain recognition complex, 40kDa; transmembrane domain recognition complex 40 kDa ATPase subunit
• UniProt Protein Name: ATPase ASNA1
• Protein Family: ATPase
• UniProt Gene Name: ASNA1
• UniProt Synonym Gene Names: ARSA; TRC40
• UniProt Entry Name: ASNA_HUMAN

NCBI Description

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Uniprot Description

ASNA1: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Belongs to the arsA ATPase family.

Protein type: Nucleolus; EC 3.6.3.16; Hydrolase; EC 3.6.-.-

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: endoplasmic reticulum; cytoplasm; nucleolus; nucleus

Molecular Function: arsenite transmembrane transporter activity; transporter activity; metal ion binding; ATPase activity; ATP binding

Biological Process: protein insertion into ER membrane; transport; inorganic anion transport; metabolic process