Mouse myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) ELISA Kit | MLL elisa kit
Mouse Histone-lysine N-methyltransferase MLL, MLL ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
MLL: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins MLL-MLLT1, MLL-MLLT3 and MLL-ELL interact with PPP1R15A and, on the contrary to unfused MLL, inhibit PPP1R15A-induced apoptosis. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Methyltransferase, protein lysine; Oncoprotein; EC 2.1.1.43; Methyltransferase; Transcription factor
Cellular Component: nucleoplasm; histone methyltransferase complex; cytoplasm; nucleus
Molecular Function: transferase activity; identical protein binding; methyltransferase activity; protein binding; protein homodimerization activity; DNA binding; unmethylated CpG binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); metal ion binding; chromatin binding; histone-lysine N-methyltransferase activity
Biological Process: methylation; transcription, DNA-dependent; embryonic hemopoiesis; positive regulation of transcription, DNA-dependent; positive regulation of transporter activity; histone H3-K4 methylation; rhythmic process; positive regulation of histone H3-K4 methylation; chromatin modification; anterior/posterior pattern formation; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; DNA methylation; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; regulation of histone H3-K4 methylation; circadian regulation of gene expression
Research Articles on MLL
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Product Notes
The Mouse MLL kmt2a (Catalog #AAA9329790) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329790 ELISA Kit recognizes Mouse MLL. It is sometimes possible for the material contained within the vial of "myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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