Human ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) ELISA Kit | RAC2 elisa kit

Human Ras-related C3 botulinum toxin substrate 2, RAC2 ELISA Kit

Cat. Num. AAA9329764

• Gene Names: RAC2; Gx; EN-7; HSPC022; p21-Rac2
• Reactivity: Human
• Synonyms: ras-related C3 botulinum toxin substrate 2 (rho family; small GTP binding protein Rac2); Human Ras-related C3 botulinum toxin substrate 2; RAC2 ELISA Kit; Human Ras-related C3 botulinum toxin substrate 2 (RAC2) ELISA kit; EN-7; Gx; HSPC022; Ras-related C3 botulinum toxin substrate 3 (rho family; small GTP-binding protein Rac2) ; ras-related C3 botulinum toxin substrate 2; rho family; small GTP binding protein Rac2; small; RAC2 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4506381
• NCBI GeneID: 5880
• NCBI Accession #: NP_002863.1
• NCBI GenBank Nucleotide #: NM_002872.4
• UniProt Accession #: P15153; Q9UDJ4; AAB22207
• Molecular Weight: 21,429 Da
• NCBI Official Full Name: ras-related C3 botulinum toxin substrate 2
• NCBI Official Synonym Full Names: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
• NCBI Official Symbol: RAC2
• NCBI Official Synonym Symbols: Gx; EN-7; HSPC022; p21-Rac2
• NCBI Protein Information: ras-related C3 botulinum toxin substrate 2; small G protein; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)
• UniProt Protein Name: Ras-related C3 botulinum toxin substrate 2
• Protein Family: Ras-related protein
• UniProt Gene Name: RAC2
• UniProt Entry Name: RAC2_HUMAN

NCBI Description

This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Uniprot Description

RAC2: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric; G protein, monomeric, Rho; G protein

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: focal adhesion; lamellipodium; plasma membrane; actin filament; nuclear envelope; cytosol

Molecular Function: GTPase activity; GTP binding

Biological Process: platelet activation; axon guidance; metabolic process; actin filament organization; cell projection biogenesis; signal transduction; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of cell proliferation; blood coagulation; bone resorption; regulation of hydrogen peroxide metabolic process

Disease: Neutrophil Immunodeficiency Syndrome