Human myosin VB ELISA Kit | MYO5B elisa kit
Human Myosin-Vb, MYO5B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Uniprot Description
MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: recycling endosome; cytoplasmic vesicle membrane; protein complex; apical cortex; myosin complex
Molecular Function: microfilament motor activity; calmodulin binding; protein binding; actin binding; Rab GTPase binding; ATP binding
Biological Process: vesicle-mediated transport; protein transport; metabolic process; water transport; renal water homeostasis; transmembrane transport; endosome localization
Disease: Diarrhea 2, With Microvillus Atrophy
Research Articles on MYO5B
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Product Notes
The Human MYO5B myo5b (Catalog #AAA9329602) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329602 ELISA Kit recognizes Human MYO5B. It is sometimes possible for the material contained within the vial of "myosin VB, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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