Human spectrin, beta, non-erythrocytic 2 ELISA Kit | SPTBN2 elisa kit
Human Spectrin beta chain, brain 2, SPTBN2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Uniprot Description
SPTBN2: Probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: spectrin; extracellular space; cell soma; cytoplasm; apical plasma membrane; cytosol; cell junction
Molecular Function: structural constituent of cytoskeleton; phospholipid binding; actin binding
Biological Process: vesicle-mediated transport; axon guidance; synaptogenesis; actin filament capping; adult behavior; multicellular organism growth; antigen processing and presentation of exogenous peptide antigen via MHC class II; cerebellar Purkinje cell layer morphogenesis
Disease: Spinocerebellar Ataxia, Autosomal Recessive 14; Spinocerebellar Ataxia 5
Research Articles on SPTBN2
Similar Products
Product Notes
The Human SPTBN2 sptbn2 (Catalog #AAA9329059) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329059 ELISA Kit recognizes Human SPTBN2. It is sometimes possible for the material contained within the vial of "spectrin, beta, non-erythrocytic 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
