Western Blot (WB)
(human brain tissue were subjected to SDS PAGE followed by western blot with MBS7604438 (SPTBN2 antibody) at dilution of 1:500)
Rabbit anti-Human, Mouse SPTBN2 Polyclonal Antibody | anti-SPTBN2 antibody
SPTBN2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(human brain tissue were subjected to SDS PAGE followed by western blot with MBS7604438 (SPTBN2 antibody) at dilution of 1:500)
Western Blot (WB)
(human brain tissue were subjected to SDS PAGE followed by western blot with MBS7604438 (SPTBN2 antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Uniprot Description
SPTBN2: Probably plays an important role in neuronal membrane skeleton. Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: apical plasma membrane; cell junction; cell soma; cytoplasm; cytosol; endosome; extracellular space; Golgi membrane; perinuclear region of cytoplasm; spectrin; synaptic vesicle
Molecular Function: actin binding; phospholipid binding; Ras guanyl-nucleotide exchange factor activity; structural constituent of cytoskeleton
Biological Process: actin filament capping; adult behavior; antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; cerebellar Purkinje cell layer morphogenesis; ER to Golgi vesicle-mediated transport; MAPKKK cascade; multicellular organism growth; positive regulation of GTPase activity; synaptogenesis; vesicle-mediated transport
Disease: Spinocerebellar Ataxia 5; Spinocerebellar Ataxia, Autosomal Recessive 14
Research Articles on SPTBN2
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Product Notes
The SPTBN2 sptbn2 (Catalog #AAA7604438) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SPTBN2 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SPTBN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the SPTBN2 sptbn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPTBN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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