Human Rho guanine nucleotide exchange factor (GEF) 12 ELISA Kit | ARHGEF12 elisa kit
Human Rho guanine nucleotide exchange factor 12, ARHGEF12 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Description
ARHGEF12: a widely-expressed guanine nucleotide exchange factor (GEF) for RhoA GTPase. May act as GTPase-activating protein (GAP) for G-alpha 12 and 13. The fusion protein MLL-ARHGEF12 appears to be a disease driver in acute myeloid leukemia. Two isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; GEFs; Oncoprotein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: membrane; cytoplasm; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; G-protein-coupled receptor binding; GTPase activator activity
Biological Process: axon guidance; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction
Research Articles on ARHGEF12
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Product Notes
The Human ARHGEF12 arhgef12 (Catalog #AAA9328842) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328842 ELISA Kit recognizes Human ARHGEF12. It is sometimes possible for the material contained within the vial of "Rho guanine nucleotide exchange factor (GEF) 12, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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