Human cytochrome P450, family 8, subfamily B, polypeptide 1 ELISA Kit | CYP8B1 elisa kit
Human 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, CYP8B1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP8B1: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. Belongs to the cytochrome P450 family.
Protein type: EC 1.14.13.95; Oxidoreductase; Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: sterol 12-alpha-hydroxylase activity; iron ion binding; heme binding; 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity; oxygen binding
Biological Process: bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; lipid metabolic process; sterol metabolic process
Research Articles on CYP8B1
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Product Notes
The Human CYP8B1 cyp8b1 (Catalog #AAA9328501) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328501 ELISA Kit recognizes Human CYP8B1. It is sometimes possible for the material contained within the vial of "cytochrome P450, family 8, subfamily B, polypeptide 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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