Rat vesicle-fusing ATPase (NSF) ELISA Kit | NSF elisa kit
Rat vesicle-fusing ATPase, NSF ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds AMPA receptor GluR2 subunit and acts to disrupt GluR2-PICK1 interactions; may play a role in AMPA receptor trafficking and stabilization [RGD, Feb 2006]
Uniprot Description
NSF: required for intracellular membrane fusion and vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns.
Protein type: Autophagy; Vesicle; Protease; EC 3.6.4.6; Adaptor/scaffold
Cellular Component: Golgi stack; lysosomal membrane; postsynaptic density; cytoplasm; plasma membrane; dendritic shaft; myelin sheath
Molecular Function: protein C-terminus binding; metal ion binding; ATPase activity; protein kinase binding; PDZ domain binding; ATP-dependent protein binding; protein binding; syntaxin binding; protein complex binding; syntaxin-1 binding; ATPase activity, coupled; D1 dopamine receptor binding; ATP binding; Rab GTPase binding
Biological Process: regulation of exocytosis; vesicle-mediated transport; vesicle fusion; intra-Golgi vesicle-mediated transport; protein transport; metabolic process; neurotransmitter secretion; Golgi to plasma membrane protein transport; Golgi vesicle docking; positive regulation of receptor recycling; potassium ion transport
Research Articles on NSF
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Product Notes
The Rat NSF nsf (Catalog #AAA9328447) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328447 ELISA Kit recognizes Rat NSF. It is sometimes possible for the material contained within the vial of "vesicle-fusing ATPase (NSF), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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