Human nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 ELISA Kit | NFATC3 elisa kit

Human Nuclear factor of activated T-cells, cytoplasmic 3, NFATC3 ELISA Kit

Cat. Num. AAA9328190

• Gene Names: NFATC3; NFAT4; NFATX
• Reactivity: Human
• Synonyms: nuclear factor of activated T-cells; cytoplasmic; calcineurin-dependent 3; Human Nuclear factor of activated T-cells; cytoplasmic 3; NFATC3 ELISA Kit; cytoplasmic 3 (NFATC3) ELISA kit; NFAT4; NFATX; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa; NFATC3 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Body fluids, tissue homogenates, secretions or feces samples
• Assay Type: Quantitative Sandwich
• Detection Range: 0.25ng/ml-8ng/ml
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for NFATC3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of NFATC3 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 4758804
• NCBI GeneID: 4775
• NCBI Accession #: NP_004546.1
• NCBI GenBank Nucleotide #: NM_004555.3
• UniProt Accession #: Q12968; O75211; Q14516; Q99840; Q99841; Q99842
• Molecular Weight: 115,594 Da
• NCBI Official Full Name: nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
• NCBI Official Synonym Full Names: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
• NCBI Official Symbol: NFATC3
• NCBI Official Synonym Symbols: NFAT4; NFATX
• NCBI Protein Information: nuclear factor of activated T-cells, cytoplasmic 3; NF-ATc3; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa
• UniProt Protein Name: Nuclear factor of activated T-cells, cytoplasmic 3
• Protein Family: Nuclear factor of activated T-cells
• UniProt Gene Name: NFATC3
• UniProt Synonym Gene Names: NFAT4; NF-ATc3; NFATc3; NF-AT4
• UniProt Entry Name: NFAC3_HUMAN

NCBI Description

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

NFAT4: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; chromatin binding

Biological Process: patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; heart development; cellular respiration; muscle cell development; innate immune response; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response