Mouse Ras and Rab interactor 1 ELISA Kit | RIN1 elisa kit

Mouse Ras and Rab interactor 1, RIN1 ELISA Kit

Cat. Num. AAA9327676

• Reactivity: Mouse
• Synonyms: Ras and Rab interactor 1; Mouse Ras and Rab interactor 1; RIN1 ELISA Kit; Mouse Ras and Rab interactor 1 (RIN1) ELISA kit; ras inhibitor 1; ras inhibitor RIN1; RIN1 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 21703974
• NCBI GeneID: 225870
• NCBI Accession #: NP_663470.1
• NCBI GenBank Nucleotide #: NM_145495.2
• UniProt Accession #: Q921Q7
• Molecular Weight: 83,014 Da
• NCBI Official Full Name: ras and Rab interactor 1
• NCBI Official Synonym Full Names: Ras and Rab interactor 1
• NCBI Official Symbol: Rin1
• NCBI Protein Information: ras and Rab interactor 1; ras interaction/interference protein 1
• UniProt Protein Name: Ras and Rab interactor 1
• Protein Family: RuvB-like protein
• UniProt Gene Name: Rin1
• UniProt Entry Name: RIN1_MOUSE

Uniprot Description

Rin1: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351. Expressed in all tissues examined with high levels in brain, placenta and pancreas. Belongs to the RIN (Ras interaction/interference) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rab

Cellular Component: cytoskeleton; cell soma; membrane; dendrite; cytoplasm; plasma membrane

Molecular Function: Ras GTPase binding; GTPase activator activity

Biological Process: negative regulation of synaptic plasticity; endocytosis; signal transduction; memory; associative learning