Mouse polymerase (RNA) I polypeptide D, 16kDa ELISA Kit | POLR1D elisa kit
Mouse DNA-directed RNA polymerases I and III subunit RPAC2, POLR1D ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Uniprot Description
POLR1D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Defects in POLR1D are the cause of Treacher Collins syndrome type 2 (TCS2). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Cellular Component: DNA-directed RNA polymerase III complex; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: protein dimerization activity; protein binding; DNA binding; DNA-directed RNA polymerase activity
Biological Process: transcription, DNA-dependent
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Product Notes
The Mouse POLR1D polr1d (Catalog #AAA9327577) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327577 ELISA Kit recognizes Mouse POLR1D. It is sometimes possible for the material contained within the vial of "polymerase (RNA) I polypeptide D, 16kDa, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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