Human vacuolar protein sorting 39 homolog (S. cerevisiae) ELISA Kit | VPS39 elisa kit
Human Vam6/Vps39-like protein, VPS39 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
VPS39: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Belongs to the VAM6/VPS39 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein regulator, misc.; Membrane protein, peripheral
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: lysosomal membrane; late endosome membrane
Biological Process: vesicle-mediated transport; intracellular protein transport; regulation of catalytic activity
Research Articles on VPS39
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Product Notes
The Human VPS39 vps39 (Catalog #AAA9327554) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327554 ELISA Kit recognizes Human VPS39. It is sometimes possible for the material contained within the vial of "vacuolar protein sorting 39 homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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